Sequence: (cholesterol)2-Lys-(Gly)2-(Arg)9
| Experiment Id | EXP002304 |
|---|---|
| Paper | Reshaping Prostate Tumor Microenvironment To Suppress Metastasis via Cancer-Associated Fibroblast In |
| Peptide | Chol-R9 |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | 1 mg/kg siRNA |
| Rna Concentration | 1 mg/kg |
| Mixing Ratio | electrostatic assembly |
| Formulation Format | peptide nanoparticle |
| Formulation Components | Chol-R9 PNP + siRNA + anti-FAPα mAb |
| Size Nm | 100.00 |
| Zeta Mv | -13.00 |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | BALB/c nude mouse orthotopic prostate tumor |
| Administration Route | intravenous |
| Output Type | tumor growth & metastasis |
| Output Value | ↓ tumor growth, ↓ metastasis |
| Output Units | |
| Output Notes | Orthotopic prostate tumor model; BLI, metastasis suppression |
| Toxicity Notes | No systemic toxicity |
| Curation Notes |