Sequence: GRKKRRQRRRCG
| Experiment Id | EXP002305 |
|---|---|
| Paper | Prolongation of Life in Rats with Malignant Glioma by Intranasal siRNA/Drug Codelivery to the Brain |
| Peptide | Tat-modified MPEG-PCL |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | polymer-based |
| Rna Concentration | 1–10 µg/mL siRNA |
| Mixing Ratio | N/P 30 |
| Formulation Format | polymeric micelle |
| Formulation Components | MPEG-PCL-Tat + CPT |
| Size Nm | 60.00 |
| Zeta Mv | 13.00 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | C6 rat glioma cells |
| Animal Model | |
| Administration Route | cell culture |
| Output Type | gene silencing / cytotoxicity |
| Output Value | Raf-1 knockdown; increased cell death |
| Output Units | |
| Output Notes | WST-8 assay; dose-dependent effect |
| Toxicity Notes | No toxicity in neuron cells |
| Curation Notes |