Sequence: 5-FAM-CGYRPVHNIRGHWAPG
| Experiment Id | EXP002313 |
|---|---|
| Paper | Crossing the blood-brain-barrier with nanoligand drug carriers self-assembled from a phage display p |
| Peptide | FAM-CGY |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | 10 µM peptide |
| Rna Concentration | 48–72 nM siRNA |
| Mixing Ratio | electrostatic assembly |
| Formulation Format | peptide assembly / NLC |
| Formulation Components | self-assembled peptide NLC |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | C57BL/6 mouse |
| Administration Route | intravenous |
| Output Type | gene knockdown |
| Output Value | ~50% BACE1 silencing in brain |
| Output Units | |
| Output Notes | Western blot hippocampus |
| Toxicity Notes | No inflammation or toxicity |
| Curation Notes |