Sequence: RRRRRRRR
| Experiment Id | EXP002333 |
|---|---|
| Paper | Near-infrared boosted ROS responsive siRNA delivery and cancer therapy with sequentially peeled upco |
| Peptide | R8 |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | UCNO multistage nanoparticle |
| Formulation Components | UCNP core + PEI-RB + PEI-SeSe/siRNA + R8 + HA |
| Size Nm | 80.00 |
| Zeta Mv | -20.00 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | HepG2; COS7 |
| Animal Model | |
| Administration Route | cell culture |
| Output Type | gene knockdown |
| Output Value | PLK1 mRNA ↓ to ~27% (with NIR) |
| Output Units | |
| Output Notes | NIR-triggered ROS induces PEI-SeSe degradation and cytosolic siRNA release |
| Toxicity Notes | Low cytotoxicity; >85% viability |
| Curation Notes |