Sequence: RRRRRRRR
| Experiment Id | EXP002334 |
|---|---|
| Paper | Near-infrared boosted ROS responsive siRNA delivery and cancer therapy with sequentially peeled upco |
| Peptide | R8 |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | UCNO multistage nanoparticle |
| Formulation Components | UCNP core + PEI-RB + PEI-SeSe/siRNA + R8 + HA |
| Size Nm | 80.00 |
| Zeta Mv | -20.00 |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | HepG2; COS7 |
| Animal Model | HepG2 xenograft nude mice |
| Administration Route | intratumoral + NIR |
| Output Type | tumor growth suppression |
| Output Value | Significant tumor inhibition vs controls |
| Output Units | |
| Output Notes | NIR-triggered ROS induces PEI-SeSe degradation and cytosolic siRNA release |
| Toxicity Notes | Low cytotoxicity; >85% viability |
| Curation Notes |