Sequence: GALFLGFLGAAGSTMGAWSQPKSKRKV
| Experiment Id | EXP002335 |
|---|---|
| Paper | Controlling fibrous capsule formation through long-term down-regulation of collagen type I (COL1A1) |
| Peptide | MPGDNLS |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | Electrospun nanofiber scaffold |
| Formulation Components | PCLEEP nanofibers + siRNA/CPP complexes |
| Size Nm | 550.00 |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | Human dermal fibroblasts (HDFs) |
| Animal Model | |
| Administration Route | scaffold-mediated (cell culture) |
| Output Type | gene knockdown |
| Output Value | Sustained COL1A1 knockdown (up to 14 days) |
| Output Units | |
| Output Notes | Scaffold-mediated delivery prolonged silencing vs bolus delivery |
| Toxicity Notes | Low cytotoxicity; improved vs TKO |
| Curation Notes |