Sequence: GLWRALWRLLRSLWRLLWRA
| Experiment Id | EXP002338 |
|---|---|
| Paper | Controlling fibrous capsule formation through long-term down-regulation of collagen type I (COL1A1) |
| Peptide | CADY |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | Electrospun nanofiber scaffold |
| Formulation Components | PCLEEP nanofibers + siRNA/CPP complexes |
| Size Nm | 550.00 |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | Human dermal fibroblasts (HDFs) |
| Animal Model | Sprague–Dawley rats (subcutaneous implant) |
| Administration Route | subcutaneous implantation |
| Output Type | fibrous capsule thickness reduction |
| Output Value | Significant reduction at weeks 2 and 4 (CADY > MPG) |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |