Sequence: RRRRRRRRR
| Experiment Id | EXP002345 |
|---|---|
| Paper | Hyaluronic acid-modified cholesterol-conjugated cell-penetrating peptides for nose-to-brain siRNA de |
| Peptide | R9-C |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | HA-coated CPP nanoparticle |
| Formulation Components | HA + cholesterol-R9-C + siRNA |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | Orthotopic glioma mouse (GL261) |
| Administration Route | intranasal |
| Output Type | tumor inhibition & survival |
| Output Value | Reduced tumor growth; prolonged survival |
| Output Units | |
| Output Notes | Nose-to-brain delivery; target gene knockdown in tumor |
| Toxicity Notes | No systemic toxicity |
| Curation Notes |