Multistage pH-responsive codelivery liposomal platform for synergistic cancer therapy (2022)
DPRP (dual pH-responsive peptide)
Sequence: Ac-CGehGehGehGehGG-benzoic imine-rrrrrrrrGC
| Experiment Id | EXP002359 |
|---|---|
| Paper | Multistage pH-responsive codelivery liposomal platform for synergistic cancer therapy |
| Peptide | DPRP (dual pH-responsive peptide) |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | pH-responsive liposome (DPRP-modified) |
| Formulation Components | DOPE/CHEMS/Chol + DSPE-PEG2000-DPRP + SA-H8 + siRNA ± DTX |
| Size Nm | 180.00 |
| Zeta Mv | 35.00 |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | MCF-7 xenograft nude mouse |
| Administration Route | intravenous |
| Output Type | tumor growth inhibition |
| Output Value | Significant tumor suppression; PLK-1 knockdown; increased TUNEL staining |
| Output Units | |
| Output Notes | Synergistic siRNA+DTX superior to single or combinatorial dosing |
| Toxicity Notes | No significant body weight loss or organ toxicity |
| Curation Notes |