Sequence: FAEKFKEAVKDYFAKFWD
| Experiment Id | EXP002360 |
|---|---|
| Paper | Lipoprotein-biomimetic nanostructure enables tumor-targeted penetration delivery for enhanced photo- |
| Peptide | D4F |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | medium |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | 100 nM (siRNA) |
| Mixing Ratio | |
| Formulation Format | HDL-mimetic nanoparticle co-loading ICG + Chol-siRNA |
| Formulation Components | rHDL/siHIF-ICG: PC + D4F + ICG + Chol-siHIF |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | U87 (glioma); bEnd.3 (BBB model) |
| Animal Model | |
| Administration Route | cell culture (± BBB transwell model; ± 808 nm laser) |
| Output Type | in vitro functional effect (HIF-1α pathway) |
| Output Value | Comparator group; functional effect weaker than ptHDL (as reported) |
| Output Units | |
| Output Notes | HDL-mimic built from D4F peptide; cholesterol-siHIF anchored in phospholipid monolayer; ICG in hydrophobic core |
| Toxicity Notes | Negligible dark cytotoxicity in bEnd.3 (reported for formulations) |
| Curation Notes |