Sequence: FAEKFKEAVKDYFAKFWDGSGCGNKRTR
| Experiment Id | EXP002364 |
|---|---|
| Paper | Lipoprotein-biomimetic nanostructure enables tumor-targeted penetration delivery for enhanced photo- |
| Peptide | tLyP-1-D4F |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | 1 mg/kg siRNA; 1.5 mg/kg ICG |
| Mixing Ratio | |
| Formulation Format | HDL-mimetic nanoparticle co-loading ICG + Chol-siRNA |
| Formulation Components | ptHDL/siHIF-ICG: PC + tLyP-1-D4F + ICG + Chol-siHIF |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | BALB/c nude mice; orthotopic RFP-U87 glioma |
| Administration Route | intravenous (tail vein) + 808 nm laser (L) |
| Output Type | tumor growth suppression & survival benefit |
| Output Value | Tumor inhibitory rate ~87.2%; prolonged median survival; reduced HIF-1α/CD31 in tumors |
| Output Units | |
| Output Notes | Tumor-penetrating HDL-mimic built from fusion peptide; improved BBB crossing, tumor homing/penetration via NRP-1 |
| Toxicity Notes | Biosafety: no obvious body-weight loss; histology/biochemistry normal (reported) |
| Curation Notes |