Sequence: cRGD-RRRRRRRRR
| Experiment Id | EXP002366 |
|---|---|
| Paper | Functionalized DMP-039 Hybrid Nanoparticle as a Novel mRNA Vector for Efficient Cancer Suicide Gene |
| Peptide | cRGD-R9 |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | 10–12 µg mRNA per dose (reported) |
| Mixing Ratio | |
| Formulation Format | Peptide-functionalized lipid–polymer hybrid nanoparticle (DMP-039) |
| Formulation Components | DOTAP + mPEG-PCL + cRGD-R9 |
| Size Nm | 268.90 |
| Zeta Mv | 17.40 |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | BALB/c mice; C26 abdominal, subcutaneous, and pulmonary metastasis models |
| Administration Route | intravenous, intraperitoneal, intratumoral |
| Output Type | tumor growth suppression and survival benefit |
| Output Value | Strong tumor inhibition, apoptosis induction, reduced metastasis |
| Output Units | |
| Output Notes | Multiple in vivo models; biodistribution and safety evaluated |
| Toxicity Notes | No significant organ toxicity or body weight loss |
| Curation Notes |