Sequence: GRKKRRQRRR
| Experiment Id | EXP002370 |
|---|---|
| Paper | Blockade of HIF-1α and STAT3 by hyaluronate-conjugated TAT-chitosan-SPION nanoparticles loaded with |
| Peptide | HIV-Tat |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | polymer-coated magnetic nanoparticle |
| Formulation Components | SPION-TMC-ChT-TAT-HA + siRNA |
| Size Nm | 118.00 |
| Zeta Mv | 20.00 |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | BALB/c mice bearing 4T1 or CT26 tumors |
| Administration Route | intravenous |
| Output Type | tumor growth suppression; survival benefit |
| Output Value | Marked tumor volume reduction and increased survival; enhanced CTL response |
| Output Units | |
| Output Notes | Dual siRNA delivery showed strongest effect |
| Toxicity Notes | Well tolerated; no major systemic toxicity reported |
| Curation Notes |