Sequence: KTLKVAKWLKKAKPLRKLVKC
SSO (2′-O-methyl oligoribonucleotide)
| Experiment Id | EXP002374 |
|---|---|
| Paper | A non-covalent strategy combining cationic lipids and CPPs to enhance delivery of splice correcting |
| Peptide | Scrambled S413-PV |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | CPP + cationic liposome ternary complex |
| Formulation Components | CPP + DOGS/DOPE liposomes + SSO |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | HeLa pLuc/705 |
| Animal Model | |
| Administration Route | cell culture transfection |
| Output Type | splice correction (luciferase reporter) |
| Output Value | Significant luciferase restoration when combined with liposomes |
| Output Units | |
| Output Notes | CPP alone ineffective; synergy with lipoplex critical |
| Toxicity Notes | No significant toxicity reported |
| Curation Notes |