Sequence: WEAALAEALAEALAEHLAEALAEALEALAA
| Experiment Id | EXP002377 |
|---|---|
| Paper | In Vivo Delivery of siRNAs Targeting EGFR and BRD4 Expression by Peptide-Modified Redox Responsive P |
| Peptide | GALA |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | peptide-modified redox-responsive polymer nanoparticle |
| Formulation Components | PEG-SS-PEI + peptide + siRNA |
| Size Nm | 80.00 |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | MDA-MB-231 xenograft nude mice |
| Administration Route | intravenous (tail vein) |
| Output Type | tumor growth inhibition and in vivo gene silencing |
| Output Value | Reduced tumor growth; decreased EGFR/BRD4 signaling |
| Output Units | |
| Output Notes | Western blot of tumor tissue; biodistribution imaging |
| Toxicity Notes | No significant systemic toxicity |
| Curation Notes |