Sequence: CREKA
| Experiment Id | EXP002378 |
|---|---|
| Paper | In Vivo Delivery of siRNAs Targeting EGFR and BRD4 Expression by Peptide-Modified Redox Responsive P |
| Peptide | CREKA |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | peptide-modified redox-responsive polymer nanoparticle |
| Formulation Components | PEG-SS-PEI + peptide + siRNA |
| Size Nm | 80.00 |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | MDA-MB-231 (TNBC) |
| Animal Model | |
| Administration Route | cell culture transfection |
| Output Type | gene knockdown |
| Output Value | Comparable knockdown to unmodified PEG-SS-PEI |
| Output Units | |
| Output Notes | CREKA mainly affects targeting, not intracellular delivery |
| Toxicity Notes | Low cytotoxicity |
| Curation Notes |