Bacterial outer membrane vesicle nanorobot (2024)
Sequence: CGKRK
| Experiment Id | EXP002385 |
|---|---|
| Paper | Bacterial outer membrane vesicle nanorobot |
| Peptide | CPP (ClyA-CPP fusion) |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | OMV-based enzyme-powered nanorobot |
| Formulation Components | CPP-OMV + urease + siRNA |
| Size Nm | 115.00 |
| Zeta Mv | 20.00 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | MBT-2 bladder cancer cells |
| Animal Model | |
| Administration Route | cell culture incubation |
| Output Type | gene knockdown; apoptosis |
| Output Value | Strong survivin mRNA/protein reduction; increased apoptosis |
| Output Units | |
| Output Notes | qPCR, Western blot, Annexin V/PI; propulsion-enhanced uptake |
| Toxicity Notes | Low toxicity at working concentrations |
| Curation Notes |