Bacterial outer membrane vesicle nanorobot (2024)
Sequence: CGKRK
| Experiment Id | EXP002386 |
|---|---|
| Paper | Bacterial outer membrane vesicle nanorobot |
| Peptide | CPP (ClyA-CPP fusion) |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | OMV-based enzyme-powered nanorobot |
| Formulation Components | CPP-OMV + urease + siRNA |
| Size Nm | 115.00 |
| Zeta Mv | 20.00 |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | Orthotopic MBT-2 bladder tumor mouse model |
| Administration Route | intravesical instillation |
| Output Type | tumor growth suppression; survival; immune activation |
| Output Value | Near-complete tumor suppression; improved survival; strong immune stimulation |
| Output Units | |
| Output Notes | Bioluminescence imaging, tumor weight, IHC, cytokines |
| Toxicity Notes | No significant systemic toxicity |
| Curation Notes |