Bioengineered Extracellular Membranous Nanovesicles for Efficient Small-Interfering RNA Delivery (2016)
Sequence: RGD
| Experiment Id | EXP002388 |
|---|---|
| Paper | Bioengineered Extracellular Membranous Nanovesicles for Efficient Small-Interfering RNA Delivery |
| Peptide | RGD |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | engineered exosome / PMNV |
| Formulation Components | RGD-modified exosome or PMNV + siRNA |
| Size Nm | 100.00 |
| Zeta Mv | 12.00 |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | Mouse (systemic injection) |
| Administration Route | intravenous |
| Output Type | in vivo gene knockdown |
| Output Value | Significant APOB knockdown in liver |
| Output Units | |
| Output Notes | qRT-PCR of liver tissue; biodistribution imaging |
| Toxicity Notes | No significant hepatotoxicity |
| Curation Notes |