CAP (cartilage-targeting peptide)
Sequence: DWRVIIPPRPSA
| Experiment Id | EXP002413 |
|---|---|
| Paper | Co-Polymer Carrier with Dual Advantages of Cartilage-Penetrating and Targeting Improves Delivery and |
| Peptide | CAP (cartilage-targeting peptide) |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | 0.5 mg/kg r-miR-140 per intra-articular injection |
| Rna Concentration | 0.5 mg/kg per dose |
| Mixing Ratio | CAP-PVAm-PLGA : r-miR-140 = 1 (w/w) |
| Formulation Format | polymeric nanoparticles (CPP-NPs) |
| Formulation Components | CAP-PVAm-PLGA copolymer + r-miR-140 |
| Size Nm | 96.00 |
| Zeta Mv | 8.80 |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | DMM-induced osteoarthritis mouse model |
| Administration Route | intra-articular injection |
| Output Type | disease modification |
| Output Value | 65% reduction in cartilage degeneration; 80% reduction in synovial inflammation |
| Output Units | |
| Output Notes | Improved cartilage integrity, subchondral bone microarchitecture, and OA scores |
| Toxicity Notes | No systemic toxicity; normal AST/ALT/BUN/CREA |
| Curation Notes |