Delivery of siRNA Using Functionalized Gold Nanorods Enhances Anti-Osteosarcoma Efficacy (2021)
Sequence: AGYLLGHINLHHLAHL(Aib)HHILCys
| Experiment Id | EXP002438 |
|---|---|
| Paper | Delivery of siRNA Using Functionalized Gold Nanorods Enhances Anti-Osteosarcoma Efficacy |
| Peptide | CPP-Pep-TH |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | GNR:siRNA 16:1; CPP ≥1:1 |
| Formulation Format | nanoparticle |
| Formulation Components | Gold nanorods, PSS, PDDAC, CPP |
| Size Nm | |
| Zeta Mv | 10.70 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | HOS, U2-OS, 143B, MG-63 |
| Animal Model | |
| Administration Route | |
| Output Type | gene knockdown / apoptosis |
| Output Value | TFEB knockdown, reduced autophagy, apoptosis with NIR |
| Output Units | |
| Output Notes | Functional silencing and cytotoxicity only in vitro |
| Toxicity Notes | |
| Curation Notes |