Delivery of siRNA Using Functionalized Gold Nanorods Enhances Anti-Osteosarcoma Efficacy (2021)
Sequence: AGYLLGHINLHHLAHL(Aib)HHILCys
| Experiment Id | EXP002439 |
|---|---|
| Paper | Delivery of siRNA Using Functionalized Gold Nanorods Enhances Anti-Osteosarcoma Efficacy |
| Peptide | CPP-Pep-TH |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | GNR:siRNA 16:1; CPP ≥1:1 |
| Formulation Format | nanoparticle |
| Formulation Components | Gold nanorods, PSS, PDDAC, CPP |
| Size Nm | |
| Zeta Mv | 10.70 |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | Nude mouse osteosarcoma xenograft (orthotopic & subcutaneous) |
| Administration Route | intravenous |
| Output Type | tumor suppression / anti-metastasis |
| Output Value | Reduced tumor volume and lung metastasis with NIR |
| Output Units | |
| Output Notes | Clear tumor suppression and reduced metastasis |
| Toxicity Notes | No major organ toxicity observed |
| Curation Notes |