Multifunctional elastin-like polypeptide nanocarriers for efficient miRNA delivery in cancer therapy (2024)
Sequence: Tat-AP1-ELP(A86)
| Experiment Id | EXP002442 |
|---|---|
| Paper | Multifunctional elastin-like polypeptide nanocarriers for efficient miRNA delivery in cancer therapy |
| Peptide | Tat-A86 |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | 5–10 µM (spheroid) |
| Mixing Ratio | miRNA:ELP = 1:20 |
| Formulation Format | nanoparticle |
| Formulation Components | Tat-A86 ELP + miRNA |
| Size Nm | 145.00 |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | LLC spheroids (3D) |
| Animal Model | |
| Administration Route | |
| Output Type | tumor spheroid inhibition |
| Output Value | Dose-dependent spheroid shrinkage and apoptosis |
| Output Units | |
| Output Notes | Strong penetration and killing in 3D tumor model |
| Toxicity Notes | Low toxicity |
| Curation Notes |