Multifunctional elastin-like polypeptide nanocarriers for efficient miRNA delivery in cancer therapy (2024)
Sequence: Tat-AP1-ELP(A86)
| Experiment Id | EXP002443 |
|---|---|
| Paper | Multifunctional elastin-like polypeptide nanocarriers for efficient miRNA delivery in cancer therapy |
| Peptide | Tat-A86 |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | 6 mg/kg miRNA |
| Mixing Ratio | miRNA:ELP = 1:20 |
| Formulation Format | nanoparticle |
| Formulation Components | Tat-A86 ELP + miRNA |
| Size Nm | 145.00 |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | LLC allograft (C57BL/6 mice) |
| Administration Route | intravenous |
| Output Type | tumor growth inhibition |
| Output Value | ~38% tumor growth suppression |
| Output Units | |
| Output Notes | Significant tumor weight reduction; apoptosis (TUNEL) |
| Toxicity Notes | No organ toxicity, stable body weight |
| Curation Notes |