Sequence: guanidine-functionalized α-helical polypeptide (polymeric, sequence not disclosed)
| Experiment Id | EXP002454 |
|---|---|
| Paper | Macrophage membrane-reversibly camouflaged nanotherapeutics accelerate fracture healing by fostering |
| Peptide | PG (α-helical polypeptide) |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | 1 mg siRNA/kg |
| Mixing Ratio | PG-based NCs |
| Formulation Format | membrane-cloaked nanocomplex |
| Formulation Components | PG/siRNA + catalase + macrophage membrane + sSDF-1α |
| Size Nm | 170.00 |
| Zeta Mv | -3.30 |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | C57BL/6 femur fracture mouse model |
| Administration Route | intravenous |
| Output Type | bone healing / gene silencing |
| Output Value | Accelerated fracture healing; improved BMD and callus formation |
| Output Units | |
| Output Notes | Robust in vivo delivery and therapeutic effect |
| Toxicity Notes | No major systemic toxicity |
| Curation Notes |