Novel peptide (RATH) mediated delivery of peptide nucleic acids for antiviral interventions (2021)
Sequence: TPWWRLWTKWHHKRRDLPRKPE
| Experiment Id | EXP002458 |
|---|---|
| Paper | Novel peptide (RATH) mediated delivery of peptide nucleic acids for antiviral interventions |
| Peptide | RATH |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | 100–200 nM PNA |
| Mixing Ratio | peptide:PNA = 16:1 |
| Formulation Format | non-covalent nanoparticle |
| Formulation Components | RATH + PNA |
| Size Nm | 179.00 |
| Zeta Mv | 2.00 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | HeLa cells |
| Animal Model | |
| Administration Route | |
| Output Type | antiviral gene silencing |
| Output Value | Up to 69.5% NDV F-gene inhibition (best with RATH-2) |
| Output Units | |
| Output Notes | RATH-2 shows highest delivery efficiency (93%) |
| Toxicity Notes | Low cytotoxicity (>95% viability) |
| Curation Notes |