Sequence: Stearyl-AGYLLG(Ka)LLOOLAAAALOOLL-NH2
antisense oligonucleotide (sense control)
| Experiment Id | EXP002483 |
|---|---|
| Paper | Novel Efficient Cell-Penetrating Peptide–Mediated Strategy for Enhancing Telomerase Inhibitor Oligon |
| Peptide | PepFect15 (PF15) |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | no |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | Defined by molar ratio |
| Rna Concentration | 100 nM |
| Mixing Ratio | PF15:ON = 9:1 (molar) |
| Formulation Format | CPP/oligonucleotide nanocomplex |
| Formulation Components | PF15 + sense control ON3 |
| Size Nm | 400.00 |
| Zeta Mv | -27.00 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | HeLa cells |
| Animal Model | |
| Administration Route | |
| Output Type | Functional enzyme inhibition (TRAP assay) |
| Output Value | No significant telomerase inhibition vs untreated |
| Output Units | |
| Output Notes | Negative control demonstrating sequence specificity |
| Toxicity Notes | No toxicity reported |
| Curation Notes |