Sequence: VSRRRRRRGGRRRR
| Experiment Id | EXP002484 |
|---|---|
| Paper | Self-assembled redox-responsive BRD4 siRNA nanoparticles: formulation and its in vitro delivery in g |
| Peptide | LMWP |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | Defined by N/P ratio |
| Rna Concentration | 40–100 nM |
| Mixing Ratio | N/P = 30 |
| Formulation Format | Polymer/CPP siRNA nanoparticles (L-NPs/siBRD4) |
| Formulation Components | LMWP–PEG–SS–PEI + BRD4 siRNA |
| Size Nm | 95.20 |
| Zeta Mv | 37.80 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | HGC-27; SGC-7901 (gastric cancer cells) |
| Animal Model | |
| Administration Route | |
| Output Type | Gene silencing; proliferation, migration, invasion assays |
| Output Value | Significant BRD4 knockdown; reduced proliferation, migration, invasion |
| Output Units | |
| Output Notes | Enhanced uptake vs PEG-SS-PEI alone; lysosomal escape observed after 6 h |
| Toxicity Notes | Low cytotoxicity at effective doses |
| Curation Notes |