Therapeutic uses of peptide nucleic acids (PNA) in oncology (2003)
Sequence: RQIKIWFQNRRMKWKK
| Experiment Id | EXP002494 |
|---|---|
| Paper | Therapeutic uses of peptide nucleic acids (PNA) in oncology |
| Peptide | pAntennapedia |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | Micromolar range |
| Rna Concentration | Micromolar range |
| Mixing Ratio | 1:1 covalent conjugate |
| Formulation Format | CPP–PNA conjugate |
| Formulation Components | pAntennapedia–PNA (disulfide-linked) |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | Human melanoma cells |
| Animal Model | |
| Administration Route | |
| Output Type | Telomerase activity (TRAP assay) |
| Output Value | Dose- and time-dependent telomerase inhibition in intact cells |
| Output Units | |
| Output Notes | Fluorescence microscopy confirms intracellular uptake; functional inhibition requires CPP conjugation |
| Toxicity Notes | Mild growth retardation; some apoptosis upon prolonged exposure |
| Curation Notes |