Cyclization and thermal modulation of a β-hairpin peptide for efficient cellular delivery (2026)
Sequence: KVKVKVKVKVKVKVKVKVKV
| Experiment Id | EXP002500 |
|---|---|
| Paper | Cyclization and thermal modulation of a β-hairpin peptide for efficient cellular delivery |
| Peptide | Ac-SVS1 |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | no |
| Endosomal Escape Evidence | no |
| Peptide Concentration | 1 µM |
| Rna Concentration | 50 nM |
| Mixing Ratio | Peptide:siRNA = 20–40:1 |
| Formulation Format | CPP/siRNA electrostatic complex |
| Formulation Components | Ac-SVS1 + siCyclinB1 |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | A549; OVCAR-3; HeLa |
| Animal Model | |
| Administration Route | |
| Output Type | Protein knockdown (Western blot) |
| Output Value | Minimal or no Cyclin B1 suppression |
| Output Units | |
| Output Notes | Predominant lysosomal colocalization; poor cytosolic release |
| Toxicity Notes | Low toxicity |
| Curation Notes |