Cyclization and thermal modulation of a β-hairpin peptide for efficient cellular delivery (2026)
Sequence: cyclo-KVKVKVKVKVKVKVKVKVKV
| Experiment Id | EXP002502 |
|---|---|
| Paper | Cyclization and thermal modulation of a β-hairpin peptide for efficient cellular delivery |
| Peptide | Cyc-SVS1 |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | 5 mg/kg |
| Rna Concentration | 125 µg per dose |
| Mixing Ratio | Peptide:siRNA ≈ 40:1 |
| Formulation Format | CPP/siRNA complex |
| Formulation Components | Cyc-SVS1 + siCyclinB1 |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | HeLa xenograft nude mouse model |
| Administration Route | Peritumoral injection |
| Output Type | Tumor growth suppression |
| Output Value | Significant tumor volume reduction; Cyclin B1 downregulation |
| Output Units | |
| Output Notes | In vivo siRNA delivery confirmed by fluorescence and IHC |
| Toxicity Notes | No significant body weight loss |
| Curation Notes |