Sequence: Ac-KCULKLULKULKACLKLUG-NH2
| Experiment Id | EXP002503 |
|---|---|
| Paper | Redox-cleavable disulfide linker enhances siRNA delivery by prodrug-type bifunctional cell-penetrati |
| Peptide | PI |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | no |
| Endosomal Escape Evidence | |
| Peptide Concentration | 1–5 µM |
| Rna Concentration | 50 nM |
| Mixing Ratio | Peptide:siRNA ≈ 20:1 |
| Formulation Format | CPP/siRNA electrostatic complex |
| Formulation Components | PI + siRNA |
| Size Nm | 220.00 |
| Zeta Mv | 18.00 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | HeLa-Luc |
| Animal Model | |
| Administration Route | |
| Output Type | Reporter gene knockdown |
| Output Value | Minimal knockdown |
| Output Units | |
| Output Notes | Cellular uptake observed but no cytosolic release |
| Toxicity Notes | Low toxicity |
| Curation Notes |