Microenvironment-tailored micelles restrain carcinoma–astrocyte crosstalk for brain metastasis (2022)
Sequence: CSKC
| Experiment Id | EXP002514 |
|---|---|
| Paper | Microenvironment-tailored micelles restrain carcinoma–astrocyte crosstalk for brain metastasis |
| Peptide | CSKC |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | Polymer-based (not isolated) |
| Rna Concentration | ~100 pmol per well |
| Mixing Ratio | G/P = 3:1 |
| Formulation Format | Targeted polymeric micelle (T-M/siRNA) |
| Formulation Components | CSKC-PEG-pArg-pLys-SS-PTX + siPCDH7 |
| Size Nm | 70.00 |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | MDA-MB-231/Luc; BCEC; primary astrocytes |
| Animal Model | |
| Administration Route | |
| Output Type | Gene knockdown and cytotoxicity |
| Output Value | Strong PCDH7 downregulation; enhanced cytotoxicity vs controls |
| Output Units | |
| Output Notes | siRNA released after GSH-triggered micelle dissociation |
| Toxicity Notes | Lower toxicity than free PTX |
| Curation Notes |