Microenvironment-tailored micelles restrain carcinoma–astrocyte crosstalk for brain metastasis (2022)
Sequence: CSKC
| Experiment Id | EXP002515 |
|---|---|
| Paper | Microenvironment-tailored micelles restrain carcinoma–astrocyte crosstalk for brain metastasis |
| Peptide | CSKC |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | 4 mg/kg PTX equiv |
| Rna Concentration | 2.5 mg/kg siRNA |
| Mixing Ratio | G/P = 3:1 |
| Formulation Format | Targeted polymeric micelle (T-M/siRNA) |
| Formulation Components | CSKC-PEG-pArg-pLys-SS-PTX + siPCDH7 |
| Size Nm | 70.00 |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | TNBC brain metastasis nude mouse model |
| Administration Route | Intravenous (tail vein) |
| Output Type | Tumor growth and survival |
| Output Value | Reduced brain metastasis burden; prolonged survival |
| Output Units | |
| Output Notes | Normalized astrocyte/microglia activation via PCDH7 silencing |
| Toxicity Notes | No significant systemic toxicity |
| Curation Notes |