Delivery of siRNA and other macromolecules into skin and cells using a peptide enhancer (2011)
Sequence: ACTGSTQHQCG
| Experiment Id | EXP002521 |
|---|---|
| Paper | Delivery of siRNA and other macromolecules into skin and cells using a peptide enhancer |
| Peptide | SPACE |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | 10 µM |
| Rna Concentration | 10 µM |
| Mixing Ratio | Covalent conjugate |
| Formulation Format | Peptide–siRNA conjugate |
| Formulation Components | SPACE–IL10 siRNA |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | Balb/C mouse skin |
| Administration Route | Topical |
| Output Type | Protein knockdown |
| Output Value | Significant IL-10 reduction |
| Output Units | |
| Output Notes | No knockdown with siRNA alone or control peptide |
| Toxicity Notes | No observable toxicity |
| Curation Notes |