Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4 (2012)
Sequence: YGRKKRRQRRR
| Experiment Id | EXP002527 |
|---|---|
| Paper | Targeted tumor-penetrating siRNA nanocomplexes for credentialing the ovarian cancer oncogene ID4 |
| Peptide | TAT |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | low |
| In Vitro Functional Effect | no |
| Endosomal Escape Evidence | |
| Peptide Concentration | Screening conditions |
| Rna Concentration | ~50 nM |
| Mixing Ratio | Exploratory |
| Formulation Format | CPP/siRNA complex |
| Formulation Components | TAT + siID4 |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | OVCAR-4; OVCAR-8 |
| Animal Model | |
| Administration Route | |
| Output Type | Gene knockdown |
| Output Value | Weak or negligible knockdown |
| Output Units | |
| Output Notes | Screened and not advanced |
| Toxicity Notes | Not emphasized |
| Curation Notes |