Sequence: HAIYPRH
| Experiment Id | EXP002531 |
|---|---|
| Paper | Brain tumor-targeted therapy by systemic delivery of siRNA with transferrin receptor-mediated core-s |
| Peptide | T7 |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | Repeated systemic dosing |
| Rna Concentration | 1 mg/kg siRNA |
| Mixing Ratio | Layer-by-layer assembly |
| Formulation Format | T7-modified core–shell nanoparticle (T7-LPC/siRNA) |
| Formulation Components | T7-PEG-DSPE + liposome + protamine/CS/siRNA core |
| Size Nm | 84.00 |
| Zeta Mv | 34.00 |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | Intracranial U87 glioma nude mouse model |
| Administration Route | Intravenous (tail vein) |
| Output Type | Tumor growth inhibition and survival |
| Output Value | Prolonged survival; strong EGFR downregulation |
| Output Units | |
| Output Notes | Efficient BBB crossing and tumor accumulation |
| Toxicity Notes | No significant systemic toxicity |
| Curation Notes |