Sequence: WEAALAEALAEALAEHLAEALAEALEALAA
| Experiment Id | EXP002532 |
|---|---|
| Paper | Lipid envelope-type nanoparticle incorporating a multifunctional peptide for systemic siRNA delivery |
| Peptide | GALA |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | 2 mol% of total lipid |
| Rna Concentration | Varied (0.2–4 mg/kg equiv in vivo) |
| Mixing Ratio | siRNA/PEI core, lipid encapsulation |
| Formulation Format | GALA-modified MEND |
| Formulation Components | siRNA/PEI core + DOTMA/EPC/Chol + Chol-GALA |
| Size Nm | 100.00 |
| Zeta Mv | 15.00 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | HMVEC-L; HUVEC |
| Animal Model | |
| Administration Route | |
| Output Type | Uptake and gene knockdown |
| Output Value | Significant CD31 knockdown |
| Output Units | |
| Output Notes | pH-dependent fusogenic peptide |
| Toxicity Notes | Low toxicity |
| Curation Notes |