Sequence: WEAALAEALAEALAEHLAEALAEALEALAA
| Experiment Id | EXP002533 |
|---|---|
| Paper | Lipid envelope-type nanoparticle incorporating a multifunctional peptide for systemic siRNA delivery |
| Peptide | GALA |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | 2 mol% of total lipid |
| Rna Concentration | 0.5–4.0 mg/kg |
| Mixing Ratio | siRNA/PEI core, lipid encapsulation |
| Formulation Format | GALA-modified MEND |
| Formulation Components | siRNA/PEI core + DOTMA/EPC/Chol + Chol-GALA |
| Size Nm | 100.00 |
| Zeta Mv | 15.00 |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | C57BL/6 mice; B16F10 lung metastasis model |
| Administration Route | Intravenous |
| Output Type | Tumor suppression and gene knockdown |
| Output Value | ~80% CD31 knockdown; ~50% metastasis reduction |
| Output Units | |
| Output Notes | Efficient lung endothelial targeting |
| Toxicity Notes | No significant toxicity |
| Curation Notes |