Sequence: YGRKKRRQRRR
| Experiment Id | EXP002534 |
|---|---|
| Paper | Development of an antisense RNA delivery system using conjugates of the MS2 bacteriophage capsids an |
| Peptide | HIV-1 Tat(47–57) |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | 100–500 nM (VLP equivalent) |
| Rna Concentration | Encapsulated |
| Mixing Ratio | Covalent conjugation |
| Formulation Format | Tat–MS2 virus-like particle |
| Formulation Components | MS2 VLP + antisense RNA + Tat peptide |
| Size Nm | 26.00 |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | Huh-7 cells (HCV luciferase reporter) |
| Animal Model | |
| Administration Route | |
| Output Type | Reporter gene inhibition |
| Output Value | Dose-dependent inhibition of HCV translation |
| Output Units | |
| Output Notes | Incomplete antisense release discussed |
| Toxicity Notes | Higher dose showed toxicity |
| Curation Notes |