Sequence: RLWMRWYSPRTRAYGC
| Experiment Id | EXP002546 |
|---|---|
| Paper | Selective Cell Penetrating Peptide-Functionalized Envelope-Type Chimeric Lipopepsomes Boost Systemic |
| Peptide | CPP33 |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | 20 mol% CPP33 on CLP surface |
| Rna Concentration | 150 nmol siPLK1 equiv. kg−1 (q2d ×4) |
| Mixing Ratio | siRNA encapsulated via PLL lumen complexation |
| Formulation Format | Envelope-type chimeric lipopepsomes (CLP) |
| Formulation Components | PEG-b-PAPA-b-PLL (80 mol%) + CPP33-PEG-b-PAPA (20 mol%) |
| Size Nm | 90.00 |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | Orthotopic A549-Luc human lung tumor xenograft in nude mice |
| Administration Route | Intravenous (tail vein) |
| Output Type | Tumor growth, survival, biodistribution |
| Output Value | Significant tumor suppression; median survival 45 days vs 26–36 days controls |
| Output Units | |
| Output Notes | Bioluminescence imaging, survival curves, biodistribution |
| Toxicity Notes | Negligible body weight loss; low systemic toxicity |
| Curation Notes |