Sequence: CRGDK
| Experiment Id | EXP002557 |
|---|---|
| Paper | Synergistically enhanced anticancer effect of codelivered curcumin and siPlk1 by stimuli-responsive |
| Peptide | RGD |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | Protein nanosphere (α-lactalbumin) |
| Formulation Components | RGD-conjugated α-lactalbumin nanospheres co-loaded with curcumin and siPlk1 |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | HeLa |
| Animal Model | |
| Administration Route | |
| Output Type | Gene and protein knockdown |
| Output Value | Plk1 mRNA reduced to ~36%; strong protein knockdown |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |