Sequence: CRGDK
| Experiment Id | EXP002558 |
|---|---|
| Paper | Synergistically enhanced anticancer effect of codelivered curcumin and siPlk1 by stimuli-responsive |
| Peptide | RGD |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | Protein nanosphere (α-lactalbumin) |
| Formulation Components | RGD-conjugated α-lactalbumin nanospheres co-loaded with curcumin and siPlk1 |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | HeLa xenograft BALB/c nude mouse |
| Administration Route | Intravenous |
| Output Type | Tumor growth suppression and survival |
| Output Value | Strong tumor inhibition, survival benefit, Plk1 knockdown in tumors |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |