Targeting the 19S proteasomal subunit, Rpt4, for the treatment of colon cancer (2016)
Sequence: RRRRRRRR
| Experiment Id | EXP002564 |
|---|---|
| Paper | Targeting the 19S proteasomal subunit, Rpt4, for the treatment of colon cancer |
| Peptide | R8 (Octa-arginine) |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | R8:siRNA 50:1 |
| Formulation Format | CPP–siRNA electrostatic nanocomplex |
| Formulation Components | R8 peptide + siRNA |
| Size Nm | 238.00 |
| Zeta Mv | 12.60 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | HCT116 colon cancer cells |
| Animal Model | |
| Administration Route | |
| Output Type | Gene knockdown and cytotoxicity |
| Output Value | Rpt4 knockdown; reduced cell viability and clonogenic survival |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |