Targeting the 19S proteasomal subunit, Rpt4, for the treatment of colon cancer (2016)
Sequence: RRRRRRRR
| Experiment Id | EXP002565 |
|---|---|
| Paper | Targeting the 19S proteasomal subunit, Rpt4, for the treatment of colon cancer |
| Peptide | R8 (Octa-arginine) |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | 0.1–1 mg/kg |
| Mixing Ratio | |
| Formulation Format | CPP–siRNA electrostatic nanocomplex |
| Formulation Components | R8 peptide + siRNA |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | HCT116 xenograft mouse model |
| Administration Route | Intratumoral injection |
| Output Type | Tumor growth and survival |
| Output Value | Reduced tumor growth and improved survival |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |