Sequence: RQIKIWFQNRRMKWKK
| Experiment Id | EXP002572 |
|---|---|
| Paper | Blood pressure reduction through brain delivery of nanoparticles loaded with plasmid DNA encoding an |
| Peptide | Penetratin |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | Peptide-functionalized liposome |
| Formulation Components | |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | Spontaneously hypertensive rat (SHR) |
| Administration Route | Intravenous |
| Output Type | Therapeutic efficacy |
| Output Value | Brain AT1r mRNA ↓ ~70%; systolic BP ↓ ~30 mmHg |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |