Sequence: GRKKRRQRRR
| Experiment Id | EXP002575 |
|---|---|
| Paper | Delivery of siRNA to the brain using a combination of nose-to-brain delivery and cell-penetrating pe |
| Peptide | Tat |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | no |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | Tat-modified PEG-PCL polymeric micelle |
| Formulation Components | MPEG-PCL conjugated with Tat peptide |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | RN33B rat neuronal cells |
| Animal Model | |
| Administration Route | |
| Output Type | Uptake and distribution |
| Output Value | Enhanced cellular uptake vs naked siRNA |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |