Sequence: GRKKRRQRRR
| Experiment Id | EXP002576 |
|---|---|
| Paper | Delivery of siRNA to the brain using a combination of nose-to-brain delivery and cell-penetrating pe |
| Peptide | Tat |
| Delivery Success Class | no |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | Tat-modified PEG-PCL polymeric micelle |
| Formulation Components | MPEG-PCL conjugated with Tat peptide |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | Sprague–Dawley rats |
| Administration Route | Intranasal |
| Output Type | Biodistribution |
| Output Value | Increased siRNA accumulation in brain via olfactory and trigeminal nerves |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |