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BPP2

Peptide ID

PEPTIDE000461

Raw sequence

Ac-GLFHAIAHFIHGGWH-mPEG-K(mPEG-TPA)-mPEG-LRKLRKRLLR

Clean backbone

GLFHAIAHFIHGGWHPEGKPEGLRKLRKRLLR

Tokenized backbone

G-L-F-H-A-I-A-H-F-I-H-G-G-W-H-P-E-G-K-P-E-G-L-R-K-L-R-K-R-L-L-R

Sequence engineering

Stereochemistry

D-form

Modifications

Retro-inverso D-peptide for RI variants; HA2 endosomal escape where indicated; PMO conjugated via thiol–maleimide

Sequence length

32

Noncanonical residues

Experiments

• EXP000527 from Efficient systemic CNS delivery of a therapeutic antisense oligonucleotide with…