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BPP10

Peptide ID

PEPTIDE000471

Raw sequence

Ac-hwgghifhaiahflg-mPEG-K(mPEG-TPA)-mPEG-rllrkrlkrlhsalrvrl

Clean backbone

HWGGHIFHAIAHFLGRLLRKRLKRLHSALRVRL

Tokenized backbone

H-W-G-G-H-I-F-H-A-I-A-H-F-L-G-R-L-L-R-K-R-L-K-R-L-H-S-A-L-R-V-R-L

Sequence engineering

Stereochemistry

D-form

Modifications

Retro-inverso D-peptide for RI variants; HA2 endosomal escape where indicated; PMO conjugated via thiol–maleimide

Sequence length

33

Noncanonical residues

Experiments

• EXP000537 from Efficient systemic CNS delivery of a therapeutic antisense oligonucleotide with…